Editing Cysticercosis (section)

====S3PVAC vaccine====
The vaccine constituted by 3 [[peptide]] synthetically produced (S3Pvac) has proven its efficacy in natural conditions of transmission.<ref name="Huerta M 2001">{{cite journal | vauthors = Huerta M, De Aluja AS, Fragoso G, Toledo A, Villalobos N, Hernandez M, Gevorkian G, Acero G, Diaz A et al. | year = 2001 | title = Synthetic peptide vaccine against ''Taenia solium'' pig cysticercosis: successful vaccination in a controlled field trial in rural Mexico | journal = Vaccine| volume = 20 | issue = 1–2| pages = 262–6 | doi = 10.1016/S0264-410X(01)00249-3 | pmid = 11567772 }}</ref> The S3PVAC vaccine so far, can be considered as the best vaccine candidate to be used in endemic areas such as Mexico (20). S3Pvac consists of three protective peptides: KETc12, KETc1 and GK1, whose sequences belong to native [[antigen]]s that are present in the different developmental stages of ''T. solium'' and other cestode parasites.<ref name="twenty" /><ref>http://www-lab.biomedicas.unam.mx/cistimex/s1.html#capitulo6 {{webarchive|url=https://web.archive.org/web/20090307202025/http://www-lab.biomedicas.unam.mx/cistimex/s1.html |date=2009-03-07 }}</ref>

Non-infected pigs from rural villages in Mexico were vaccinated with S3Pvac and the vaccine reduced 98% the number of cysticerci and 50% the number of prevalence.<ref name="Huerta M 2001"/><ref>{{cite journal | vauthors = Sciutto E, Morales J, Martinez JJ, Toledo A, Villalobos MN, Cruz-Revilla C, Meneses G, Hernandez M, Diaz A et al. | year = 2007 | title = Further evaluation of the synthetic peptide vaccine S3Pvac against ''Taenia solium'' cysticercosis in pigs in an endemic town of Mexico | journal = Parasitology | volume = 134 | issue = Pt 1| pages = 129–33 | doi = 10.1017/S0031182006001132 | pmid = 16948875 | s2cid = 27758572 }}</ref> The diagnostic method involves necropsy and tongue inspection of pigs. The natural challenge conditions used in the study proved the efficacy of the S3Pvac vaccine in transmission control of ''T. solium'' in Mexico.<ref name="twenty" /> The S3Pvac vaccine is owned by the National Autonomous University of Mexico and the method of high scale production of the vaccine has already been developed.<ref name="twenty" /> The validation of the vaccine in agreement with the Secretary of Animal Health in Mexico is currently in the process of completion.<ref name="twenty seven">E-mail interview with Edda Sciutto. Feb 26 2009.</ref> It is also hoped that the vaccine will be well-accepted by pig owners because they also lose their income if pigs are infected cysticercosis.<ref name="twenty seven" /> Vaccination of pigs against cysticercosis, if succeeded, can potentially have a great impact on transmission control since there is no chance of re-infection once pigs receive vaccination.{{cn|date=November 2020}}