Human–animal hybrid

In this 19th-century piece by Edward Burne-Jones, the human woman Psyche receives affection from the hybrid deity Pan.

The term human-animal hybrid or animal-human hybrid refers to an entity that incorporates elements from both humans and non-human animals. For thousands of years, these hybrids have been one of the most common themes in storytelling about animals throughout the world. The lack of a strong divide between humanity and animal nature in multiple traditional and ancient cultures has provided the underlying historical context for the popularity of tales where humans and animals have mingling relationships, such as in which one turns into the other or in which some mixed being goes through a journey. Interspecies friendships within the animal kingdom, as well as between humans and their pets, additionally provides an underlying root for the popularity of such beings.

In various mythologies throughout history, many particularly famous hybrids have existed, including as a part of Egyptian and Indian spirituality. According to artist and scholar Pietro Gaietto, "representations of human-animal hybrids always have their origins in religion". As well, "successive traditions they may change in meaning but they still remain within spiritual culture" in his view. The entities have also been characters in fictional media more recently in history such as in H.G. Wells' work The Island of Doctor Moreau, adapted into the popular 1932 film Island of Lost Souls. In legendary terms, the hybrids have play varying roles from that of trickster and/or villain to serving as divine heroes in very different contexts, depending on the given culture.

For example, Pan is a deity in Greek mythology that rules over and symbolizes the untamed wild, being worshiped by hunters, fishermen, and shepherds in particular. The mischievous yet cheerful character has the hindquarters, legs, and horns of a goat while otherwise being essentially human in appearance, with stories of his encounters with different gods, humans, and others being retold for centuries on after the days of early Greece by groups such as the Delphian Society. Specifically, the human-animal hybrid has appeared in acclaimed works of art by figures such as Francis Bacon. Additional famous mythological hybrids include the Egyptian god of death, named Anubis, and the fox-like Japanese beings that are called Kitsune.

When looked at scientifically, outside of a fictional and/or mythical context, the real-life creation of human-animal hybrids has served as a subject of legal, moral, and technological debate in the context of recent advances in genetic engineering. Defined by the magazine H+ as "genetic alterations that are blendings [sic] of animal and human forms", such hybrids may be referred by other names occasionally such as "para-humans". They may additionally may be called "humanized animals". Technically speaking, they are also related to "cybrids" (cytoplasmic hybrids), with "cybrid" cells featuring foreign human nuclei inside of them being a topic of interest. Possibly, a real-world human-animal hybrid may be an entity formed from either a human egg fertilized by a nonhuman sperm or a nonhuman egg fertilized by a human sperm. While at first being a concept in the likes of legends and thought experiments, the first stable human-animal chimeras (not technically hybrids, yet related) to actually exist were first created by Shanghai Second Medical University scientists in 2003, the result of having fused human cells with rabbit eggs.

In terms of scientific ethics, restrictions on the creation of human-animal hybrids have proved a controversial matter in multiple countries. While the state of Arizona banned the practice altogether in 2010, a proposal on the subject that sparked some interest in the United States Senate from 2011 to 2012 ended up going nowhere. Although the two concepts are not strictly related, discussions of experimentation into blended human and animal creatures has paralleled the discussions around embryonic stem-cell research (the 'stem cell controversy'). The creation of genetically modified organisms for a multitude of purposes has taken place in the modern world for decades, examples being specifically designed foodstuffs made to have features such as higher crop yields through better disease resistance.

Despite the legal and moral controversy over the possible real-life making of such beings, the concept of humanoid creatures with hybrid characteristics from animals, played in a dramatic and sensationalized fashion, has continued to be a popular element of fictional media in the digital age. Examples include Splice, a 2009 movie about experimental genetic research, and The Evil Within, a survival horror video game released in 2014 in which the protagonist fights grotesque hybrid creatures among other enemies.

Legendary historical and mythological hybrids

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The pig-like hybrid being Chu Pa-chieh, pictured in this piece of fan art, plays a major role in the famous Chinese religious novel Journey to the West.

Beings displaying a mixture of human and animal traits while also having a similarly blended appearance have played a vast and varied role in multiple traditions around the world. Artist and scholar Pietro Gaietto has written that "representations of human-animal hybrids always have their origins in religion". In "successive traditions they may change in meaning but they still remain within spiritual culture", Gaietto has argued, when looking back in an evolution-minded point of view. The beings show up in both Greek and Roman mythology, with various elements of ancient Egyptian society ebbing and flowing into those cultures in particular. Prominent examples in ancient Egyptian religion, featuring some of the earliest such hybrid beings, include the canine-like god of death known as Anubis and the lion-like Sphinx. Other instances of these types of characters include figures within both Chinese and Japanese mythology. The observation of interspecies friendships within the animal kingdom, as well as the bonds existing between humans and their pets, have been a source of the appeal in such stories.

A prominent hybrid figure that's internationally known is the mythological Greek figure of Pan. A deity that rules over and symbolizes the untamed wild, he helps express the inherent beauty of the natural world as the Greeks saw things. He specifically received reverence by ancient hunters, fishermen, shepherds, and other groups with a close connection to nature. Pan possesses the hindquarters, legs, and horns of a goat while otherwise being essentially human in appearance; stories of his encounters with different gods, humans, and others have been a part of popular culture in several different cultures for many years. The human-animal hybrid has appeared in acclaimed works of art by figures such as Francis Bacon, also being mentioned in poetic pieces such as in John Fletcher's writings.

In Chinese mythology, the figure of Chu Pa-chieh undergoes a personal journey in which he gives up wickedness for virtue. After causing a disturbance in heaven from his licentious actions, he is exiled to Earth. By mistake, he enters the womb of a sow and ends up being born as a half-man/half-pig entity. With the head and ears of a pig coupled with a human body, his already animal-like sense of selfishness from his past life remains. Killing and eating his mother as well as devouring his brothers, he makes his way to a mountain hideout, spending his days preying on unwary travelers unlucky enough to cross his path. However, the exhortations of the kind goddess Kuan Yin, journeying in China, persuade him to seek a nobler path, and his life's journey and the side of goodness proceeds on such that he even is ordained a priest by the goddess herself. Remarking on the character's role in the religious novel Journey to the West, where the being first appears, professor Victor H. Mair has commented that "[p]ig-human hybrids represent descent and the grotesque, a capitulation to the basest appetites" rather than "self-improvement".

Several hybrid entities have long played a major role in Japanese media and in traditional beliefs within the country. For example, a warrior god known as Amida received worship as a part of Japanese mythology for many years; he possessed a generally humanoid appearance while having a canine-like head. However, the god's devotional popularity fell in about the middle of the 19th century. A Tanuki resembles a raccoon or badger, but its shape-shifting talents allow it to turn into humans for the purposes of trickery, such as impersonating Buddhist monks. The fox-like creatures known as Kitsune also possess similar powers, and stories abound of them tricking human men into marriage by turning into seductive women.

Other examples include characters in ancient Anatolia and Mesopotamia. The latter region has had the tradition of a malevolent human-animal hybrid deity in Pazuzu, the demon featuring a humanoid shape yet having grotesque features such as sharp talons. The character picked up revived attention when an interpretation of it appeared in William Peter Blatty's 1971 novel The Exorcist and the Academy Award winning 1973 film adaption of the same name, with the demon possessing the body of an innocent young girl. The movie, regarded as one of the greatest horror films of all time, has a prologue in which co-protagonist Father Merrin (Max von Sydow) visits an archaeological dig in Iraq and ominously discovers an old statue of the monstrous being.

Modern portrayals of fictional hybrids

The Kemonomimi art style, widely popularized since the latter part of the 20th century, involves humanoid characters with stylized animal features, such as this mouse girl.

Writer H. G. Wells created his famous work The Island of Doctor Moreau, featuring a mixture of horror and science fiction elements, to promote the anti-vivisection cause as a part of his long-time advocacy for animal rights. Wells' story describes a man stuck on an island ruled over by the titular Dr. Moreau, a morally depraved scientist who has created several human-animal hybrids. The story has been adapted into film several times, with varying success. The most notable and acclaimed version is the 1932 black-and-white treatment called Island of Lost Souls.

Wells himself wrote that "this story was the response of an imaginative mind to the reminder that humanity is but animal rough-hewn to a reasonable shape and in perpetual internal conflict between instinct and injunction," with the scandals surrounding Oscar Wilde being the impetus for the English writer's treatment of themes such as ethics and psychology. Challenging the Victorian era viewpoints of its time, the 1896 work presents a complex situation in which enhancing animals into hybrids involves both terrifying violence and pain as well as appears essentially futile, given the power of raw instinct. A pessimistic view towards the ability of human civilization to live by law-abiding, moral standards for long thus follows.

The science fiction film Splice, released 2009, shows scientists mixing together human and animal DNA in the hopes of advancing medical research. Calamitous results occur. The 1986 horror film The Fly features a deformed and monstrous human-animal hybrid, played by actor Jeff Goldblum. His character, scientist Seth Brundle, undergoes a teleportation experiment that goes awry and fuses him at a fundamental genetic level with a common fly caught besides him. Brundle experiences drastic mutations as a result that horrify him. Movie critic Gerardo Valero has written that the famous horror work, "released at the dawn of the AIDS epidemic", "was seen by many as a metaphor for the disease" while also playing on bodily fears about dismemberment and coming apart that human beings inherently share.

In terms of comic books, examples of fictional human-animal hybrids include the characters in Charles Burns’ Black Hole series. In those comics, a set of teenagers in a 1970s era town become afflicted by a bizarre disease; the sexually transmitted affliction mutates them into monstrous forms.

Multiple video games have featured human-animal hybrids as enemies for the protagonist(s) to defeat, including powerful boss characters. For instance, the 2014 survival horror release The Evil Within includes grotesque hybrid beings, looking like the undead, attacking main character Detective Sebastian Castellanos. With partners Joseph Oda and Julie Kidman, the protagonist attempts investigate a multiple homicide at a mental hospital yet discovers a mysterious figure who turns the world around them into a living nightmare, Castellanos having to find the truth about the criminal psychopath.

Scientific research and related issues

Background and technological analyses

Broadly speaking, a hybrid being has one cell line throughout its entire body and came originally from a mix of entities, with different species involved to make a new genetic combination. For instance, a liger has a lion father and a tigress mother, such a creature only existing in captivity. A chimera is not the same thing as a hybrid because it is a being composed of two or more genetically distinct cell lines in one entity; it does not exist as a member of a separate species but has differing elements inside of it.

For much of modern history, the creation of genetically modified organisms in general was a topic rooted in fiction rather than practical research. This has changed significantly over the past few decades such that a number of plants and animals are commonly subject to genetic engineering for commercial purposes. For example, as of 2013 about 85% of the corn grown in the U.S. as well as about 90% of its canola crops have been genetically modified. As well, many Americans that have had cardiovascular surgery have had heart valves initially from pigs used in their procedures.

In terms of human evolution, hybridization occurred frequently, such as cross-breeding between Neanderthals and ancient versions of what are now modern humans. Some scientifists have believed that particular genes of the Neanderthal may have been key to ancient humans' adapting to the harsh climates they faced when they left Africa.

Issues relating to possible human-animal hybrids outside of a fictional, historical, and/or mythic context but as real, engineered beings received major international attention in 2003, after some Chinese scientists at the Shanghai Second Medical University managed to successfully fuse human cells with rabbit eggs. The embryos formed reportedly were the first stable human-animal chimeras in existence. Research in similar areas continued into 2004 and 2005, with the topic picking up coverage from publications such as National Geographic News. The National Academy of Sciences soon began to look into the ethical questions involved. The U.S. Patent and Trademark Office additionally stirred interest into the topic by granting a patent request for a genetically modified mouse with a human immune system.

Legal and moral discussions

Advances in genetic engineering have caused a large amount of debates and discussion in the fields related to bioethics, and research relating to the hypothetical creation of human-animal hybrids in the future has been no exception. The technical analyses of intermingling human-based and animal-based genetic material are ongoing; the ethical, moral, and legal issues arising from actual research using chimeras (rather than hybrids per se) at the moment also touch more speculative concerns as well. While laws against the creation of hybrid beings have been proposed in U.S. states and in the U.S. Congress, several scientists have argued that legal barriers might go too far and prohibit medically beneficial studies into human modification.

For instance, Dr. Douglas Kniss, head of the Laboratory of PeriNatal Research at Ohio State University, has publicly remarked that formal laws aren't the best option since the "notion of animal-human hybrids is very complex." He's also argued that their creation is inherently "not the kind of thing we support" in his kind of research since scientists should "want to respect human life". "There are chimeras out there that serve very valuable purposes in medical research, such as mice that make human antibodies," Michael Werner, the chief of policy for the Biotechnology Industry Organization, has remarked.

See also

• Anthropomorphism
• Human-animal bonding
• Human-animal communication
• Human-animal studies
• Humanzee
• Hybrid
• Interspecies friendships
• List of legendary creatures by type
• Mythic animal
• Mythic humanoids
• Mythological hybrid
• Posthuman
• Transhumanism
• Trial of Thomas Hogg
• Zoophilia